Why Your Vitamin B12 Didn’t Help You!

At Primera Specialty Infusion, we see many patients who are struggling with fatigue, brain fog, or low energy—even after trying over-the-counter B12 supplements or even standard B12 injections. The truth is, not all forms of B12 are created equal, and for some people, the “regular” version simply doesn’t get the job done.

Why Standard B12 May Fall Short

Most supplements and injections contain cyanocobalamin, the most common form of vitamin B12. Before your body can use it, cyanocobalamin has to be converted in the liver into its active form. For many individuals—especially women with hormone changes, genetic variations like MTHFR, or absorption issues—this conversion process doesn’t work efficiently.

Patients living with inflammatory bowel disease (IBD), such as Crohn’s disease or ulcerative colitis, often face an even greater challenge. Because B12 is absorbed in the small intestine, inflammation or past surgeries can make it difficult for their bodies to take in and convert enough of this vitamin. That’s why so many people with IBD continue to feel drained despite oral supplementation or standard B12 injections.

The Power of Methylated B12

That’s where methylcobalamin (pre-methylated B12) comes in. This form is already active, meaning your body can use it immediately without any extra conversion steps. For patients who haven’t responded to standard B12—whether in pill, liquid, or injection form—or who have absorption barriers due to IBD, methylcobalamin can be life-changing.

Benefits of Methylated B12 Injections

• Restored Energy – Supports cellular energy production to combat fatigue and help you feel more vibrant.
   
• Nervous System Health – Protects nerve cells and may reduce symptoms like tingling or numbness.
   
• Sharper Focus & Memory – Supports brain health for better concentration and clarity.
   
• Mood & Hormone Balance – Plays a role in neurotransmitter function and overall mood regulation.
   
• Whole-Body Wellness – Supports detoxification, hormone regulation, and DNA repair through the methylation process.
   

Who Benefits Most?

• Women experiencing fatigue, mood swings, or hormonal imbalance
   
• Patients with IBD (Crohn’s disease, ulcerative colitis) and absorption challenges
   
• Those with MTHFR gene mutations
   
• Individuals struggling with brain fog or neuropathy
   
• Anyone not improving with regular oral supplements or standard B12 injections
   

Putting Patients Primera

At Primera Specialty Infusion, we offer methylcobalamin injections that bypass the digestive system and deliver this active nutrient directly where your body needs it most. Many of our patients notice an almost immediate difference in energy, clarity, and overall well-being.

If you’ve been taking regular B12—or even receiving standard injections—without results, don’t lose hope. Your body may simply need a different form. Our team is here to help you find the right solution so you can feel your best again.

Because every patient is unique, we recommend a personalized consultation to determine if methylated B12 is right for you.

Putting Patients Primera means finding the form of care that works for you.

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