When Gout Won’t Go Away: How KRYSTEXXA® Helps Patients Finally Find Relief

For most people, gout flares come and go! Painful, yes, but manageable with medication and diet changes.
But for some, gout becomes a constant companion. The pain lingers. The swelling spreads. The joints grow stiff and deformed. And nothing seems to work anymore.

If that sounds familiar, you may be dealing with uncontrolled gout, a serious form of chronic gout that goes beyond occasional flares.

Understanding Gout: More Than Just “Too Much Uric Acid”

Gout happens when uric acid builds up in the blood and forms sharp crystals that deposit in the joints. Those crystals trigger inflammation, causing the intense pain, redness, and swelling known as a “flare.”

Over time, high uric acid can lead to joint damage, visible lumps called tophi, and even kidney complications.
Normally, medications like allopurinol or febuxostat help lower uric acid, but not for everyone. Some patients’ bodies simply can’t get the levels low enough, no matter how hard they try.

That’s where KRYSTEXXA® (pegloticase) comes in.

How KRYSTEXXA® Works

KRYSTEXXA® is the only FDA-approved biologic therapy designed specifically for adults with chronic gout that hasn’t responded to other treatments.

Instead of just slowing down uric acid production like oral medicines do, KRYSTEXXA® actually breaks down uric acid in the bloodstream, converting it into a harmless substance your body can easily eliminate.

That means it doesn’t just manage gout , it targets the root cause.

In clinical studies, many patients saw:

• Rapid and sustained drops in uric acid levels
• Noticeable reduction in painful tophi
• Fewer flares over time
• Improved mobility and quality of life

When given alongside methotrexate, KRYSTEXXA® has been shown to increase treatment success rates and reduce the chance of infusion reactions, making it even more effective.

What to Expect During Treatment

KRYSTEXXA® is given as an IV infusion every two weeks in a clinical setting under the supervision of trained healthcare providers.

Before starting therapy, patients typically undergo:

• Comprehensive lab screening, including G6PD testing
• Consultation and treatment planning with a provider familiar with gout management
• Education on what to expect before, during, and after each infusion

Infusions usually take about two hours, and most patients relax during the procedure while being monitored for comfort and safety.

For those concerned about cost, there are patient assistance programs available to help reduce out-of-pocket expenses for eligible individuals.

Real Relief for Real People

For many people living with chronic gout, KRYSTEXXA® represents something they thought they’d never have again , hope.

By dramatically lowering uric acid and dissolving years of crystal buildup, this treatment can reverse the damage gout has caused and help patients regain mobility, comfort, and confidence.

For patients who have tried everything else without success, KRYSTEXXA® offers a new way forward, one based on proven science and real-world results.

Is KRYSTEXXA® Right for You?

If you’ve tried standard gout medications and still experience:

• Frequent flares
• Pain or stiffness that doesn’t go away
• Visible tophi or joint deformity
• High uric acid despite treatment

…then KRYSTEXXA® might be an option worth exploring.

Talk to your rheumatologist or primary care provider about whether KRYSTEXXA® is right for you. They can order the necessary lab work, discuss the treatment plan, and help you take the next step toward long-term relief.

Let’s Put Pain in the Past

Uncontrolled gout doesn’t have to define your life.
With the right therapy, and the right care team,  it’s possible to move freely again, without constant pain or fear of the next flare.

KRYSTEXXA® helps dissolve years of uric acid buildup and gives patients a chance to restore not just their mobility, but their quality of life.

Life is too beautiful to live in pain. Ask your doctor if KRYSTEXXA® could be right for you.

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